Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012;79(2):101-6.
doi: 10.1159/000335164. Epub 2012 Jan 27.

Pathobiological implications of MUC16/CA125 expression in intrahepatic cholangiocarcinoma-mass forming type

Michiyo Higashi  1 , Norishige Yamada, Seiya Yokoyama, Sho Kitamoto, Kazuhiro Tabata, Chihaya Koriyama, Surinder K Batra, Suguru Yonezawa
Affiliations
Free article

Pathobiological implications of MUC16/CA125 expression in intrahepatic cholangiocarcinoma-mass forming type

Michiyo Higashi et al. Pathobiology. 2012.
Free article

Abstract

Objectives: MUC16 carries the peptide epitope CA125, which is well known as a marker of ovarian cancer. High serum levels of MUC16 (CA125) have been reported not only in patients with ovarian cancer but also in patients with liver diseases. We evaluated the expression of MUC16 in intrahepatic cholangiocarcinoma-mass forming type (ICC-MF) tissues.

Methods: We examined the expression of MUC16 by immunohistochemical analyses using the monoclonal antibody M11 in ICC-MF tissues from 63 patients. To compare the prevalence of each mucin expression by clinicopathological features, appropriate statistical analysis was performed.

Results: MUC16 was detected in 48% of samples (30/63). After adjusting for the effects of other prognostic factors, multivariate survival analysis revealed that MUC16 expression is a significant independent factor of poor prognosis (p = 0.005).

Conclusion: The current results indicate that MUC16 expression is a prognostic factor of poor survival in ICC-MF.

PubMed Disclaimer

Publication types

MeSH terms