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. 2012 Apr 4;48(27):3288-90.
doi: 10.1039/c2cc17656d. Epub 2012 Jan 27.

Blending Baeyer-Villiger monooxygenases: using a robust BVMO as a scaffold for creating chimeric enzymes with novel catalytic properties

Hugo L van Beek  1 , Gonzalo de Gonzalo, Marco W Fraaije
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Blending Baeyer-Villiger monooxygenases: using a robust BVMO as a scaffold for creating chimeric enzymes with novel catalytic properties

Hugo L van Beek et al. Chem Commun (Camb). .

Abstract

The thermostable Baeyer-Villiger monooxygenase (BVMO) phenylacetone monooxygenase (PAMO) is used as a scaffold to introduce novel selectivities from other BVMOs or the metagenome by structure-inspired subdomain exchanges. This yields biocatalysts with new preferences in the oxidation of sulfides and the Baeyer-Villiger oxidation of ketones, all while maintaining most of the original thermostability.

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