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. 2012 Jan 29.
doi: 10.1007/s11883-012-0228-1. Online ahead of print.

Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis

Tanu Goyal  1 , Sona Mitra, Magomed Khaidakov, Xianwei Wang, Sandeep Singla, Zufeng Ding, Shijie Liu, Jawahar L Mehta
Affiliations

Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis

Tanu Goyal et al. Curr Atheroscler Rep. .

Abstract

Atherosclerosis is characterized by accumulation of lipids and inflammatory cells in the arterial wall. Oxidized low-density lipoprotein (ox-LDL) plays important role in the genesis and progression of atheromatous plaque. Various scavenger receptors have been recognized in the past two decades that mediate uptake of ox-LDL leading to formation of foam cells. Inhibition of scavenger receptor A and CD36 has been shown to affect progression of atherosclerosis by decreasing foam cell formation. Lectin-type oxidized LDL receptor 1 (LOX-1) participates at various steps involved in the pathogenesis of atherosclerosis, and in experimental studies its blockade has been shown to affect the progression of atherosclerosis at multiple levels. In this review, we summarize the role of ox-LDL and scavenger receptors in the formation of atheroma with emphasis on effects of LOX-1 blockade.

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References

    1. Cardiovasc Res. 2008 Jul 15;79(2):287-93 - PubMed
    1. J Am Coll Cardiol. 2003 Feb 5;41(3):360-70 - PubMed
    1. Biochem Biophys Res Commun. 2001 Oct 5;287(4):962-8 - PubMed
    1. Circ J. 2007 May;71(5):681-7 - PubMed
    1. Arterioscler Thromb Vasc Biol. 2000 Dec;20(12):2593-9 - PubMed

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