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Editorial
. 2012 Jan;3(1):1-2.
doi: 10.18632/oncotarget.435.

Histone code, human growth and cancer

Francesco Crea
Editorial

Histone code, human growth and cancer

Francesco Crea. Oncotarget. 2012 Jan.

Abstract

Future studies should shed new light on the complex relationship between HPTMs and human development. In particular, the molecular function of EZH2 and NSD1 in bone development should be addressed. Moreover, histone methylation and demethylation may be modulated by novel small molecule inhibitors[10, 11], which may pave the way to a therapeutic approach for those rare syndromes.

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Comment on

  • Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height.
    Tatton-Brown K, Hanks S, Ruark E, Zachariou A, Duarte Sdel V, Ramsay E, Snape K, Murray A, Perdeaux ER, Seal S, Loveday C, Banka S, Clericuzio C, Flinter F, Magee A, McConnell V, Patton M, Raith W, Rankin J, Splitt M, Strenger V, Taylor C, Wheeler P, Temple KI, Cole T; Childhood Overgrowth Collaboration; Douglas J, Rahman N. Tatton-Brown K, et al. Oncotarget. 2011 Dec;2(12):1127-33. doi: 10.18632/oncotarget.385. Oncotarget. 2011. PMID: 22190405 Free PMC article.

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