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. 2012 Apr;21(2):135-48.
doi: 10.1177/0962280212437479. Epub 2012 Jan 26.

An urn based covariate adjusted response adaptive allocation design

Uttam Bandyopadhyay  1 , Rahul Bhattacharya
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An urn based covariate adjusted response adaptive allocation design

Uttam Bandyopadhyay et al. Stat Methods Med Res. 2012 Apr.

Abstract

An urn based covariate adjusted response adaptive allocation design with dichotomous responses is proposed incorporating the ordered nature of the covariate. The allocation procedure is assessed both numerically and theoretically. The performance of the allocation design is also investigated in a relevant hypothetical clinical trial.

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