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Review
. 2012 Jan 31;13(3):153-62.
doi: 10.1038/nrg3188.

Understanding transgenerational epigenetic inheritance via the gametes in mammals

Lucia Daxinger  1 , Emma Whitelaw
Affiliations
Review

Understanding transgenerational epigenetic inheritance via the gametes in mammals

Lucia Daxinger et al. Nat Rev Genet. .

Abstract

It is known that information that is not contained in the DNA sequence - epigenetic information - can be inherited from the parent to the offspring. However, many questions remain unanswered regarding the extent and mechanisms of such inheritance. In this Review, we consider the evidence for transgenerational epigenetic inheritance via the gametes, including cases of environmentally induced epigenetic changes. The molecular basis of this inheritance remains unclear, but recent evidence points towards diffusible factors, in particular RNA, rather than DNA methylation or chromatin. Interestingly, many cases of epigenetic inheritance seem to involve repeat sequences.

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References

    1. Nature. 2008 Apr 17;452(7189):877-81 - PubMed
    1. Nucleic Acids Res. 2000 Sep 1;28(17):3301-9 - PubMed
    1. Trends Genet. 2011 Oct;27(10):389-96 - PubMed
    1. Science. 2010 Aug 6;329(5992):682-5 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17046-9 - PubMed

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