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. 2012 Jul;47(7):666-73.
doi: 10.1002/ppul.22501. Epub 2012 Jan 30.

Maternal smoking during pregnancy, prematurity and recurrent wheezing in early childhood

Rachel G Robison  1 , Rajesh Kumar, Lester M Arguelles, Xiumei Hong, Guoying Wang, Stephanie Apollon, Anthony Bonzagni, Kathryn Ortiz, Colleen Pearson, Jacqueline A Pongracic, Xiaobin Wang
Affiliations

Maternal smoking during pregnancy, prematurity and recurrent wheezing in early childhood

Rachel G Robison et al. Pediatr Pulmonol. 2012 Jul.

Abstract

Background: Prenatal maternal smoking and prematurity independently affect wheezing and asthma in childhood.

Objective: We sought to evaluate the interactive effects of maternal smoking and prematurity upon the development of early childhood wheezing.

Methods: We evaluated 1,448 children with smoke exposure data from a prospective urban birth cohort in Boston. Maternal antenatal and postnatal exposure was determined from standardized questionnaires. Gestational age was assessed by the first day of the last menstrual period and early prenatal ultrasound (preterm < 37 weeks gestation). Wheezing episodes were determined from medical record extraction of well and ill/unscheduled visits. The primary outcome was recurrent wheezing, defined as ≥ 4 episodes of physician documented wheezing. Logistic regression models and zero inflated negative binomial regression (for number of episodes of wheeze) assessed the independent and joint association of prematurity and maternal antenatal smoking on recurrent wheeze, controlling for relevant covariates.

Results: In the cohort, 90 (6%) children had recurrent wheezing, 147 (10%) were exposed to in utero maternal smoke and 419 (29%) were premature. Prematurity (odds ratio [OR] 2.0; 95% confidence interval [CI], 1.3-3.1) was associated with an increased risk of recurrent wheezing, but in utero maternal smoking was not (OR 1.1, 95% CI 0.5-2.4). Jointly, maternal smoke exposure and prematurity caused an increased risk of recurrent wheezing (OR 3.8, 95% CI 1.8-8.0). There was an interaction between prematurity and maternal smoking upon episodes of wheezing (P = 0.049).

Conclusions: We demonstrated an interaction between maternal smoking during pregnancy and prematurity on childhood wheezing in this urban, multiethnic birth cohort.

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References

    1. Hoyert DL, Mathews TJ, Menacker F, Strobino DM, Guyer B. Annual summary of vital statistics: 2004. Pediatrics. 2006;117(1):168–183. - PubMed
    1. Alati R, Al Mamun A, O'Callaghan M, Najman JM, Williams GM. In utero and postnatal maternal smoking and asthma in adolescence. Epidemiology. 2006;17(2):138–144. - PubMed
    1. Braback L, Bjor O, Nordahl G. Early determinants of first hospital admissions for asthma and acute bronchitis among Swedish children. Acta Paediatr. 2003;92(1):27–33. - PubMed
    1. Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2001;163(2):429–436. - PubMed
    1. Jaakkola JJ, Kosheleva AA, Katsnelson BA, Kuzmin SV, Privalova LI, Spengler JD. Prenatal and postnatal tobacco smoke exposure and respiratory health in Russian children. Respir Res. 2006;7:48. - PMC - PubMed

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