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Review
. 2012 Jan:60:29-41.
doi: 10.1016/j.pnmrs.2011.06.001. Epub 2011 Jun 12.

In vivo magnetic resonance spectroscopy of GABA: a methodological review

Nicolaas A J Puts  1 , Richard A E Edden
Affiliations
Review

In vivo magnetic resonance spectroscopy of GABA: a methodological review

Nicolaas A J Puts et al. Prog Nucl Magn Reson Spectrosc. 2012 Jan.
No abstract available

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Figures

Fig. 1
Fig. 1
MR spectra of GABA. (a) 1H MR spectrum of the human brain acquired at 3T, showing peaks corresponding to N-acetyl aspartate (NAA), creatine-containing compounds (Cr), choline-containing compounds (Cho), Myoinositol (Myo), glutamate (Glu), glutamine (Gln) and GABA. Coloured bars correspond to the simulated peak locations in (b). (b) Simulated MR spectrum of GABA at 3T, showing the assignments to the GABA CH2 spins. (c) Simulated MR spectra of GABA, Glu and Gln at a range of field strengths.
Fig. 2
Fig. 2
Comparison of multiplets in 1D spectrum and 2DJ spectrum at 3T showing (a) an isolated triplet, and separation of two overlapping triplets and (b) J-PRESS spectrum acquired at 3T.
Fig. 3
Fig. 3
Literature review. (a) Histogram of brain regions studied (OCC occipital; PAR parietal; SM sensorimotor; FRO frontal; ACC anterior cingulate; BG basal ganglia; Th Thalamus). (b) Plot of ‘SNR’ metric (volume × √(experiment time)) against year of publication. (c) Plot of ‘SNR’ metric divided by field strength against year of publication.
See this image and copyright information in PMC

References

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    1. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed. 2001;14:260–264. - PubMed

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