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. 2012 May;22(5):389-95.
doi: 10.1097/FPC.0b013e3283505d5e.

PharmGKB summary: caffeine pathway

Caroline F Thorn  1 , Eleni Aklillu, Ellen M McDonagh, Teri E Klein, Russ B Altman
Affiliations

PharmGKB summary: caffeine pathway

Caroline F Thorn et al. Pharmacogenet Genomics. 2012 May.
No abstract available

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Figures

Fig. 1
Fig. 1
Stylized liver cell depicting candidate genes involved in the pharmacokinetics of caffeine. The major route of metabolism to paraxanthine is highlighted by a bold arrow, and the key enzyme, CYP1A2, by a star. A fully interactive version is available online at http://www.pharmgkb.org/pathway/PA165884757. AFMU, 5-acetylamino-6-formylamino-3-methyluracil; CYP, cytochrome P450; NAT2, N-acetyl transferase 2; 17U, 1,7-dimethyluric acid; 17X, 1,7-dimethylxanthine; XDH, xanthine dehydrogenase.
See this image and copyright information in PMC

References

    1. Mandel HG. Update on caffeine consumption, disposition and action. Food Chem Toxicol. 2002;40:1231–1234. - PubMed
    1. Sawynok J. Methylxanthines and pain. Handb Exp Pharmacol. 2011;200:311–329. - PubMed
    1. Kot M, Daniel WA. Caffeine as a marker substrate for testing cytochrome P450 activity in human and rat. Pharmacol Rep. 2008;60:789–797. - PubMed
    1. Donovan JL, DeVane CL. A primer on caffeine pharmacology and its drug interactions in clinical psychopharmacology. Psychopharmacol Bull. 2001;35:30–48. - PubMed
    1. Prediger RD. Effects of caffeine in Parkinson’s disease: from neuroprotection to the management of motor and non-motor symptoms. J Alzheimers Dis. 2010;20(Suppl 1):S205–S220. - PubMed

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