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. 2012 Apr;5(4):1011-8.
doi: 10.3892/mmr.2012.773. Epub 2012 Jan 30.

Distinct peak at 3.8 ppm observed by 3T MR spectroscopy in meningiomas, while nearly absent in high-grade gliomas and cerebral metastases

Evanthia Kousi  1 , Ioannis Tsougos, Konstantinos Fountas, Kiriaki Theodorou, Evaggelia Tsolaki, Ioannis Fezoulidis, Eftichia Kapsalaki
Affiliations

Distinct peak at 3.8 ppm observed by 3T MR spectroscopy in meningiomas, while nearly absent in high-grade gliomas and cerebral metastases

Evanthia Kousi et al. Mol Med Rep. 2012 Apr.

Abstract

The purpose of the present study was to evaluate distinct metabolic features of meningiomas to distinguish them from other brain lesions using proton magnetic resonance spectroscopy. The study was performed on 17 meningiomas, 24 high-grade gliomas and 9 metastases. Elevated signal intensity at 3.8 ppm observed in low TE spectra adequately differentiated meningioma from other brain tumors while alanine was not indicative of meningioma occurrence; the presence of lipids and lactate did not provide a strong index for meningioma malignancy.

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Figures

Figure 1
Figure 1
FLAIR (A and B) T2 images of two of the typical meningiomas with their corresponding spectra (B and D) at short TE (35 m/sec). Elevated Cho and lipid resonances at 3.2 and 1.3 ppm, respectively. Also a distinct chemical compound was detected in all cases of meningiomas, resonating at 3.8 ppm.
Figure 2
Figure 2
In vivo short (A, C and E) and (B, D and F) mean spectra and standard deviation (vertical lines) of the 3 tumor groups. Obvious elevation of Cho and lipid resonances at 3.2 and 1.3 ppm, respectively, for all tumors. Also a distinct chemical compound (black arrow) at 35 m/sec detected in all cases of meningiomas, resonating at 3.8 ppm but not for high-grade gliomas and metastases.
Figure 3
Figure 3
FLAIR (A) and FSE (C) T2 images of high-grade gliomas and metastases respectively with their corresponding spectra (B and D), at short TE (35 m/sec).
Figure 4
Figure 4
FSE (A) T2 image of a typical meningiomas with its corresponding spectra (B). Elevated Cho in 3.2 ppm and absence of N-Acetyl-aspartate in 2.02 ppm at long TE (144 m/sec). Ala douplet inversion at 1.47 ppm suggestive of meningioma.
Figure 5
Figure 5
FLAIR (A and C) T2 images of high-grade gliomas (A) and metastases (C) respectively, with their corresponding spectra (B and D) at long TE (144 m/sec).
See this image and copyright information in PMC

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