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. 2012 Jul;64(7):2398-403.
doi: 10.1002/art.34412.

Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia

Vitaly Napadow  1 , Jieun Kim, Daniel J Clauw, Richard E Harris
Affiliations

Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia

Vitaly Napadow et al. Arthritis Rheum. 2012 Jul.

Abstract

Objective: A major impediment to the development of novel treatment strategies for fibromyalgia (FM) is the lack of an objective marker that reflects spontaneously reported clinical pain in patients with FM. Studies of resting-state intrinsic brain connectivity in FM have demonstrated increased insular connectivity to the default mode network (DMN), a network whose activity is increased during nontask states. Moreover, increased insular connectivity to the DMN was associated with increased spontaneous pain levels. However, as these analyses were cross-sectional in nature, they provided no insight into dynamic changes in connectivity or their relationship to variations in self-reported clinical pain. The purpose of this study was to evaluate longitudinal changes in the intrinsic brain connectivity of FM patients treated with nonpharmacologic interventions known to modulate pain levels in this patient population, and to test the hypothesis that the reduction of DMN-insula connectivity following therapy would correlate with diminished pain.

Methods: Seventeen FM patients underwent resting-state functional magnetic resonance imaging at baseline and following 4 weeks of a nonpharmacologic intervention to diminish pain. Intrinsic DMN connectivity was evaluated using probabilistic independent components analysis. Longitudinal changes in intrinsic DMN connectivity were evaluated by paired analysis, and correlations between longitudinal changes in clinical pain and changes in intrinsic DMN connectivity were investigated by multiple linear regression analysis. Changes in clinical pain were assessed with the short form of the McGill Pain Questionnaire (SF-MPQ).

Results: Clinical pain as assessed using the sensory scale of the SF-MPQ was reduced following therapy (P=0.02). Intrinsic DMN connectivity to the insula was reduced, and this reduction correlated with reductions in pain (corrected P<0.05).

Conclusion: Our findings suggest that intrinsic brain connectivity can be used as a candidate objective marker that reflects changes in spontaneous chronic pain within individual FM patients. We propose that intrinsic connectivity measures could potentially be used in either research or clinical settings as a complementary, more objective outcome measure for use in FM.

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Figures

Figure 1
Figure 1
Clinical pain levels were assessed just prior to fMRI scanning. There was a significant reduction in pain on the McGill Sensory subscale (p<0.05) and a trend (p=0.09) for diminished pain on the McGill affective subscale following therapy. n.b. * = p<0.05, + = 0.05 < p < 0.1
Figure 2
Figure 2
DMN connectivity to the anterior insula, which was positive at baseline, was significantly reduced following therapy.
Figure 3
Figure 3
A multiple linear regression analysis demonstrated that the change in age-adjusted clinical pain at the time of the scan was correlated (r=0.81) with reduced intrinsic DMN connectivity to the left anterior insula. A sub-threshold cluster was also found in the right posterior insula (r=0.79). n.b. aIns=anterior insula, pIns=posterior insula
See this image and copyright information in PMC

References

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