Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan 31;125(4):620-37.
doi: 10.1161/CIRCULATIONAHA.111.023838.

Epidemiology and genetics of sudden cardiac death

Rajat Deo  1 , Christine M Albert
Affiliations

Epidemiology and genetics of sudden cardiac death

Rajat Deo et al. Circulation. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Incidence of sudden cardiac arrest according to age, sex, and race in the Chicago CPR project. The study population was comprised of 6,451 patients including 3,207 whites and 2,910 blacks.
Figure 2
Figure 2
Structural Heart Disease in Cardiac Arrest Survivors. These pie charts depict the proportions of underlying cardiac disease among men and women who survive out-of-hospital cardiac arrests. The mean age was 58±12 years for men and 55±17 years for women. Coronary artery disease comprised the principal diagnosis in the majority of men. In contrast, women had more nonischemic heart disease compared to men including dilated cardiomyopathy (19%) and valvular heart disease (13%). CAD indicates coronary artery disease; DCM, dilated cardiomyopathy; VHD, valvular heart disease; SPASM, coronary vasospasm; and RV, right ventricular.
Figure 3
Figure 3
Relative risk of cardiac arrest in blacks compared to whites by age group. The bars represent 95% confidence intervals.
Figure 4
Figure 4
Critical Pathways Leading to Electrical Instability and Sudden Cardiac Death. HTN indicates hypertension; CHD, coronary heart disease; CHF, congestive heart failure; LV, left ventricular; PUFA, polyunsaturated fatty acids; NEFA, non-esterified fatty acids; and SCD, sudden cardiac death.
Figure 5
Figure 5
Underlying arrhythmias of sudden cardiac arrest. VT indicates ventricular tachycardia; and VF, ventricular fibrillation.
Figure 6
Figure 6
Sports engaged in at the time of the SCD events. There were a total of 820 SCD events evaluated in this study. N refers to the absolute number of SCD events that occurred during the specified sport. The percentage refers to the percent of deaths engaged in the specific activity. The pink shaded region represents the number of women. SDs indicate sudden deaths.
Figure 7
Figure 7
Overview of genetic studies. Genome-wide association studies aim to identify common allelic variants that have a low relative risk of disease. Evolution will select for variants that carry a high relative risk of disease; as a result, they will be rare.
See this image and copyright information in PMC

References

    1. Lopshire JC, Zipes DP. Sudden cardiac death: Better understanding of risks, mechanisms, and treatment. Circulation. 2006;114:1134–1136. - PubMed
    1. Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G, Moss AJ, Myerburg RJ, Priori SG, Quinones MA, Roden DM, Silka MJ, Tracy C, Smith SC, Jr, Jacobs AK, Adams CD, Antman EM, Anderson JL, Hunt SA, Halperin JL, Nishimura R, Ornato JP, Page RL, Riegel B, Blanc JJ, Budaj A, Dean V, Deckers JW, Despres C, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo JL, Zamorano JL. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association task force and the European Society of Cardiology committee for practice guidelines (writing committee to develop guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death): Developed in collaboration with the European Heart Rhythm association and the Heart Rhythm Society. Circulation. 2006;114:e385–484. - PubMed
    1. Fishman GI, Chugh S, DiMarco JP, Albert CM, Anderson ME, Bonow, Buxton AE, Chen P-S, Estes M, Jouven X, Kwong R, Lathrop DA, Mascette AM, Nerbonne JM, O’Rourke B, Page RL, Roden DM, Rosenbaum DS, Sotoodehnia N, Trayanova NA, Zheng Z-J. Sudden cardiac death prediction and prevention report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society workshop. Circulation. 2010;122:2335–2348. - PMC - PubMed
    1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger VL, Rosamond W, Sacco R, Sorlie P, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J. Heart disease and stroke statistics--2010 update: A report from the American Heart Association. Circulation. 2010;121:e46–e215. - PubMed
    1. Kong MH, Fonarow GC, Peterson ED, Curtis AB, Hernandez AF, Sanders GD, Thomas KL, Hayes DL, Al-Khatib SM. Systematic review of the incidence of sudden cardiac death in the United States. J Am Coll Cardiol. 2011;57:794–801. - PMC - PubMed

Publication types

MeSH terms