Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;7(1):47-9.
doi: 10.2174/157340311795677699.

Treatment of Heyde's Syndrome by Aortic Valve Replacement

Ramzi Abi-Akar  1 , Issam El-Rassi, Nicole Karam, Yehya Jassar, Rita Slim, Victor Jebara
Affiliations

Treatment of Heyde's Syndrome by Aortic Valve Replacement

Ramzi Abi-Akar et al. Curr Cardiol Rev. 2011 Feb.

Abstract

Heyde's syndrome is the association between calcific aortic stenosis and gastrointestinal bleeding due to angiodysplasia. Alterations in von Willebrand factor due to turbulence across the diseased aortic valve have been incriminated in the pathophysiology of this syndrome. Replacement of the aortic valve has been reported to stop the bleeding, but this is debatable. Along with a review of the relevant medical literature, we hereby report a 68 year old patient with aortic stenosis and severe recurrent gastrointestinal bleeding that completely subsided following aortic valve replacement.

Keywords: Aortic valve; angiodysplasia; bleeding.; gastrointestinal hemorrhage; von willebrand.

PubMed Disclaimer

References

    1. Bourdette D, Greenberg B. Twelve year history of gastrointestinal bleeding in a patient with calcific aortic stenosis and hemorrhagic telangiectasia. Dig Dis Sci. 1979;24(1):77–9. - PubMed
    1. Mishra PK, Kovac J, Caestecker J, et al. Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association. Eur J Cardiothorac Surg. 2009;35(4):628–34. - PubMed
    1. Natwitz L, Defrelingne J, Limet R. Association of aortic stenosis and gastrointestinal bleeding (Heyde's syndrome) Actra Chir Belg. 1993;93:31–3. - PubMed
    1. Massyn M, Khan S. Heyde syndrome: a common diagnosis in older patients with severe aortic stenosis. Age Aging. 2009;38(3):267–70. - PubMed
    1. Soran H, Lewis M, Whorwell P. Bleeding angiodysplasia: Should we concentrate more on the aortic valve than on the bowel ? Int J Clin Pract. 2002;56(2):155–6. - PubMed