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. 2012 Feb 29;134(8):3679-82.
doi: 10.1021/ja2120629. Epub 2012 Feb 10.

Copper-catalyzed aerobic [3+2]-annulation of N-alkenyl amidines

Yi-Feng Wang  1 , Xu Zhu, Shunsuke Chiba
Affiliations

Copper-catalyzed aerobic [3+2]-annulation of N-alkenyl amidines

Yi-Feng Wang et al. J Am Chem Soc. .

Abstract

A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines. These cyclic amidines could be converted into mono-benzyl-protected vicinal diamines by the reduction with aluminum hydride.

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