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Meta-Analysis
. 2011 Dec;26(8):627-30.
doi: 10.1177/1533317511432735. Epub 2012 Jan 31.

Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population

Jian-Fang Ma  1 , Li-hua Liu, Yu Zhang, Ying Wang, Yu-Lei Deng, Yue Huang, Gang Wang, Wei Xu, Pei-Jing Cui, Qing-Zhou Fei, Jian-Qing Ding, Hui-Dong Tang, Sheng-Di Chen
Affiliations
Meta-Analysis

Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population

Jian-Fang Ma et al. Am J Alzheimers Dis Other Demen. 2011 Dec.

Erratum in

  • Am J Alzheimers Dis Other Demen. 2013 Nov;28(7):715

Abstract

Objective: We conducted a case-control study to investigate whether clusterin polymorphism (rs11136000) was associated with late-onset Alzheimer's disease in Chinese Han population.

Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer's disease and 143 control individuals. Previous published data from other Chinese samples was also included for further meta-analysis.

Results: APOEε4 was demonstrated to increase the risk of Alzheimer's disease in Chinese population (odds ratio = 2.35, 95% confidence interval: 1.40-3.96). There is no significant association between clusterin rs11136000 with late-onset sporadic AD in our small cohort. However, meta-analysis revealed significant allele and genotype differences between Alzheimer's disease and controls following a recessive model.

Conclusion: Clusterin (rs11136000) was associated with Alzheimer's disease in Chinese Han population.

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Conflict of interest statement

The authors declared no conflicts of interest with respect to the research, authorship, and/or publication of this article.

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References

    1. Dubois B, Feldman HH, Jacova C, et al. . Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007;6(8):734–746. - PubMed
    1. Reitz C, Brayne C, Mayeux R. Epidemiology of Alzheimer disease. Nat Rev Neurol. 2011;7(3):137–152. - PMC - PubMed
    1. Raber J, Huang Y, Ashford J. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging. 2004;25(5):641–650. - PubMed
    1. Harold D, Abraham R, Hollingworth P, et al. . Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nat Genet. 2009;41(10):1088–1093. - PMC - PubMed
    1. Lambert JC, Heath S, Even G, et al. . Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Nat Genet. 2009;41(10):1094–1099. - PubMed

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