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Meta-Analysis
. 2011 Dec;26(8):627-30.
doi: 10.1177/1533317511432735. Epub 2012 Jan 31.

Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population

Jian-Fang Ma  1 , Li-hua Liu, Yu Zhang, Ying Wang, Yu-Lei Deng, Yue Huang, Gang Wang, Wei Xu, Pei-Jing Cui, Qing-Zhou Fei, Jian-Qing Ding, Hui-Dong Tang, Sheng-Di Chen
Affiliations
Meta-Analysis

Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population

Jian-Fang Ma et al. Am J Alzheimers Dis Other Demen. 2011 Dec.

Erratum in

  • Am J Alzheimers Dis Other Demen. 2013 Nov;28(7):715

Abstract

Objective: We conducted a case-control study to investigate whether clusterin polymorphism (rs11136000) was associated with late-onset Alzheimer's disease in Chinese Han population.

Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer's disease and 143 control individuals. Previous published data from other Chinese samples was also included for further meta-analysis.

Results: APOEε4 was demonstrated to increase the risk of Alzheimer's disease in Chinese population (odds ratio = 2.35, 95% confidence interval: 1.40-3.96). There is no significant association between clusterin rs11136000 with late-onset sporadic AD in our small cohort. However, meta-analysis revealed significant allele and genotype differences between Alzheimer's disease and controls following a recessive model.

Conclusion: Clusterin (rs11136000) was associated with Alzheimer's disease in Chinese Han population.

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Conflict of interest statement

The authors declared no conflicts of interest with respect to the research, authorship, and/or publication of this article.

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