Hormone action during aging: alterations and mechanisms

Abstract

The ability to respond to certain hormones is altered during the aging process. Attempts to elucidate the mechanisms involved in such changes have focused primarily on the various molecular components which mediate hormone actions. These include chromatin, the nucleus, cytoplasmic factors, adenylate cyclase and hormone receptors. Age related changes have been observed at all of these levels, and in some cases have been correlated with changes in biological responsiveness to particular hormones. This review attempts to summarize the data obtained in these studies. Possible interpretations are discussed and future directions for such research are suggested.