Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Feb;20(2):246-9.
doi: 10.1038/mt.2011.288.

Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?

Adham S Bear  1 , Richard A Morgan, Kenneth Cornetta, Carl H June, Gwendolyn Binder-Scholl, Mark E Dudley, Steven A Feldman, Steven A Rosenberg, Sheila A Shurtleff, Cliona M Rooney, Helen E Heslop, Gianpietro Dotti
Affiliations

Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?

Adham S Bear et al. Mol Ther. 2012 Feb.
No abstract available

PubMed Disclaimer

References

    1. Rosenberg SA., and, Dudley ME. Adoptive cell therapy for the treatment of patients with metastatic melanoma. Curr Opin Immunol. 2009;21:233–240. - PMC - PubMed
    1. Brenner MK., and, Heslop HE. Adoptive T cell therapy of cancer. Curr Opin Immunol. 2010;22:251–257. - PMC - PubMed
    1. Vera JF, Brenner MK., and, Dotti G. Immunotherapy of human cancers using gene modified T lymphocytes. Curr Gene Ther. 2009;9:396–408. - PMC - PubMed
    1. Hacein-Bey-Abina S, von Kalle KC, Schmidt M, Le Deist F, Wulffraat N, McIntyre E.et al. (2003A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency N Engl J Med 348255–256. - PubMed
    1. Donahue RE, Kessler SW, Bodine D, McDonagh K, Dunbar C, Goodman S.et al. (1992Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer J Exp Med 1761125–1135. - PMC - PubMed

Publication types