[Contemporary determinations of sarcoidosis ethiopathogenesis]

Abstract

Sarcoidosis is a disease about unknown etiology. It's characterized by a chronic inflammation with creation of granuloma consisted of macrophages, lymphocytes and epithelial cells. The course of the disease may be different--from spontaneous remission to severe and chronic form. The most possible cause of sarcoidosis seems to be genetic etiology. Many trials indicated strong influence of human leukocyte antigens (HLA), cytokines and chemokines on sarcoidosis origin. On the other side the role of environmental factors, viral, atypical bacterial and mycobacterial infections is strongly stressed.