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. 2012 Feb 3;335(6068):551.
doi: 10.1126/science.1215369.

Nanoscopy in a living mouse brain

Sebastian Berning  1 , Katrin I Willig, Heinz Steffens, Payam Dibaj, Stefan W Hell
Affiliations

Nanoscopy in a living mouse brain

Sebastian Berning et al. Science. .

Abstract

We demonstrated superresolution optical microscopy in a living higher animal. Stimulated emission depletion (STED) fluorescence nanoscopy reveals neurons in the cerebral cortex of a mouse with <70-nanometer resolution. Dendritic spines and their subtle changes can be observed at their relevant scales over extended periods of time.

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