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Randomized Controlled Trial
. 2012 Apr;29(4):325-8.
doi: 10.1007/s10815-012-9714-1.

Vitamin E effect on controlled ovarian stimulation of unexplained infertile women

Nedim Cicek  1 , Ozlem Gun Eryilmaz, Esma Sarikaya, Cavidan Gulerman, Yasemin Genc
Affiliations
Randomized Controlled Trial

Vitamin E effect on controlled ovarian stimulation of unexplained infertile women

Nedim Cicek et al. J Assist Reprod Genet. 2012 Apr.

Abstract

Purpose: To determine Vit E effect on the treatment outcomes of women with unexplained infertility undergoing controlled ovarian stimulation and intrauterine insemination (IUI).

Methods: The study group (Group A, n053) underwent controlled ovarian stimulation with clomiphene citrate with Vit E administration, 400 IU/day p.o. while the control group(Group B, n050) underwent ovulation induction without VitE. Treatment outcomes were compared between the groups.

Results: There were no significant differences between the two groups with respect to the demographic outcomes. The difference in endometrial thickness on the day of hCG administration was significant between the two groups (p00.001).The effect of receiving Vit E on the implantation and the on going pregnancy rates were assesed Odds Ratio (OR) and corresponding 95% Confidence Intervals (CI). Receiving Vit E was not significantly associated with the implantation and the ongoing pregnancy rates; OR 0 1.22, 95% CI (0.44–3.4)and OR 0 1.43, 95% CI (0.49–4.1), respectively.

Conclusion: Vit E administration may improve the endometrial response in unexplained infertile women via the likely antioxidant and the anticoagulant effects. It may also modulate the antiestrogenic effect of clomiphene citrate and the problem of a thin endometrium in these cycles may beadjusted

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References

    1. Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol. 2006;18:325–332. doi: 10.1097/01.gco.0000193003.58158.4e. - DOI - PubMed
    1. Riley RC, Behrman HR. Oxygen radicals and reactive oxygen species in reproduction. Proc Soc Exp Biol Med. 1991;198:781–791. - PubMed
    1. Roselli M, Keller PJ, Dubey RK. Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Hum Reprod Update. 1998;4:3–24. doi: 10.1093/humupd/4.1.3. - DOI - PubMed
    1. Sugino N, Karube-Harada A, Taketani T, et al. Withdrawl of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activationvia oxygen radicals in human endometrial stromal cells:potential relevance to mensturation. J Reprod Dev. 2004;50:215–225. doi: 10.1262/jrd.50.215. - DOI - PubMed
    1. Palamanda JR, Kehrer JP. Involvement of vitamin E and protein thiols in the inhibition of microsomal lipid peroxidation by glutathione. Lipids. 1993;28(5):427–431. doi: 10.1007/BF02535941. - DOI - PubMed

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