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. 2012 Feb;86(2):246-253.
doi: 10.4269/ajtmh.2012.11-0409.

Infectious etiologies of acute febrile illness among patients seeking health care in south-central Cambodia

Matthew R Kasper, Patrick J Blair, Sok Touch, Buth Sokhal, Chadwick Y Yasuda, Maya Williams, Allen L Richards, Timothy H Burgess, Thomas F Wierzba, Shannon D Putnam

Infectious etiologies of acute febrile illness among patients seeking health care in south-central Cambodia

Matthew R Kasper et al. Am J Trop Med Hyg. 2012 Feb.

Abstract

The agents of human febrile illness can vary by region and country suggesting that diagnosis, treatment, and control programs need to be based on a methodical evaluation of area-specific etiologies. From December 2006 to December 2009, 9,997 individuals presenting with acute febrile illness at nine health care clinics in south-central Cambodia were enrolled in a study to elucidate the etiologies. Upon enrollment, respiratory specimens, whole blood, and serum were collected. Testing was performed for viral, bacterial, and parasitic pathogens. Etiologies were identified in 38.0% of patients. Influenza was the most frequent pathogen, followed by dengue, malaria, and bacterial pathogens isolated from blood culture. In addition, 3.5% of enrolled patients were infected with more than one pathogen. Our data provide the first systematic assessment of the etiologies of acute febrile illness in south-central Cambodia. Data from syndromic-based surveillance studies can help guide public health responses in developing nations.

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Conflict of interest statement

Disclosure: This work was prepared as part of the authors' official duties. Title 17 U.S.C. §105 provides that “Copyright protection under this title is not available for any work of the United States Government.” Title 17 U.S.C. §101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person’s official duties.

Figures

Figure 1.
Figure 1.
Flow chart of patient enrollment, information collected, and testing algorithms.
Figure 2.
Figure 2.
Catchment area (gray) of febrile surveillance study.
Figure 3.
Figure 3.
Enrollment by month Dec. 2006–Dec. 2009
See this image and copyright information in PMC

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