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. 2011 May 24:2:22.
doi: 10.3389/fgene.2011.00022. eCollection 2011.

MicroRNAs: New Players in Multiple Myeloma

Flavia Pichiorri  1 , Luciana De Luca, Rami I Aqeilan
Affiliations

MicroRNAs: New Players in Multiple Myeloma

Flavia Pichiorri et al. Front Genet. .

Abstract

MicroRNAs (miRNAs) are short non-coding RNAs that play critical roles in numerous cellular processes through post-transcriptional regulating functions. The aberrant role of miRNAs has been reported in a number of hematopoietic malignancies including multiple myeloma (MM). In this review we summarize the current knowledge on roles of miRNAs in the pathogenesis of MM.

Keywords: MDM2; miRNAs; microarray; multiple myeloma; p53; profiling.

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Figures

Figure 1
Figure 1
Schematic drawing showing the multistep molecular process of PC transformation. Representative list of the miRNAs and genes significantly deregulated in MGUS and MM patients versus normal PCs.
See this image and copyright information in PMC

References

    1. A.C.S (2010). Multiple Myeloma. Available at http://www.cancer.org/Cancer/MultipleMyeloma/index
    1. Ambros V. (2003). MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 113, 673–67610.1016/S0092-8674(03)00428-8 - DOI - PubMed
    1. Ambros V. (2004). The functions of animal microRNAs. Nature 431, 350–35510.1038/nature02871 - DOI - PubMed
    1. Anderson K. C. (2011). Oncogenomics to target myeloma in the bone marrow microenvironment. Clin. Cancer Res. 17, 1225–123310.1158/1078-0432.CCR-10-3366 - DOI - PubMed
    1. Aqeilan R. I., Calin G. A., Croce C. M. (2010). miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ. 17, 215–22010.1038/cdd.2009.69 - DOI - PubMed