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Comment
. 2012 Feb 3;148(3):389-91.
doi: 10.1016/j.cell.2012.01.026.

Innate immunity to TB: a druggable balancing act

Ajit Lalvani  1 , Marcel A Behr, Saranya Sridhar
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Comment

Innate immunity to TB: a druggable balancing act

Ajit Lalvani et al. Cell. .
Free article

Abstract

Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a critical role for the genetically determined balance between pro- and anti-inflammatory eicosanoids in regulating TNFα levels provides a roadmap to tailored TB treatment based on host genotype.

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