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Comment
. 2012 Feb 3;148(3):392-4.
doi: 10.1016/j.cell.2012.01.025.

Immune cells exploit a neural circuit to enter the CNS

Kevin J Tracey  1
Affiliations
Comment

Immune cells exploit a neural circuit to enter the CNS

Kevin J Tracey. Cell. .

Abstract

Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a specific spinal cord location. T cell entry into the CNS is regulated by a reflex neural circuit originating from leg muscle contractions.

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Figures

Figure 1
Figure 1. Neural Reflex Circuits Control Function of the Immune System
As described in the text, the inflammatory reflex and the “gateway reflex” modulate the innate and adaptive immune responses to threat.
See this image and copyright information in PMC

Comment on

References

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