Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2012 Feb;87(2):143-50.
doi: 10.1016/j.mayocp.2011.10.006.

Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial

Ann E Stapleton  1 , James Dziura, Thomas M Hooton, Marsha E Cox, Yuliya Yarova-Yarovaya, Shu Chen, Kalpana Gupta
Affiliations
Randomized Controlled Trial

Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial

Ann E Stapleton et al. Mayo Clin Proc. 2012 Feb.

Abstract

Objective: To compare the time to urinary tract infection (UTI) and the rates of asymptomatic bacteriuria and urinary P-fimbriated Escherichia coli during a 6-month period in women ingesting cranberry vs placebo juice daily.

Patients and methods: Premenopausal women with a history of recent UTI were enrolled from November 16, 2005, through December 31, 2008, at 2 centers and randomized to 1 of 3 arms: 4 oz of cranberry juice daily, 8 oz of cranberry juice daily, or placebo juice. Time to UTI (symptoms plus pyuria) was the main outcome. Asymptomatic bacteriuria, adherence, and adverse effects were assessed at monthly visits.

Results: A total of 176 participants were randomized (120 to cranberry juice and 56 to placebo) and followed up for a median of 168 days. The cumulative rate of UTI was 0.29 in the cranberry juice group and 0.37 in the placebo group (P=.82). The adjusted hazard ratio for UTI in the cranberry juice group vs the placebo group was 0.68 (95% confidence interval, 0.33-1.39; P=.29). The proportion of women with P-fimbriated urinary E coli isolates during the intervention phase was 10 of 23 (43.5%) in the cranberry juice group and 8 of 10 (80.0%) in the placebo group (P=.07). The mean dose adherence was 91.8% and 90.3% in the cranberry juice group vs the placebo group. Minor adverse effects were reported by 24.2% of those in the cranberry juice group and 12.5% in the placebo group (P=.07).

Conclusion: Cranberry juice did not significantly reduce UTI risk compared with placebo. The potential protective effect we observed is consistent with previous studies and warrants confirmation in larger, well-powered studies of women with recurrent UTI. The concurrent reduction in urinary P-fimbriated E coli strains supports the biological plausibility of cranberry activity.

Trial registration: clinicaltrials.gov Identifier: NCT00128128.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Study flow chart.
FIGURE 2
FIGURE 2
Kaplan-Meier curve for time to symptomatic urinary tract infection (UTI) in women ingesting cranberry juice (orange line) vs placebo juice (blue line). No significant difference was found in time to UTI between the groups (P=.41; log-rank test).
See this image and copyright information in PMC

References

    1. Dielubanza E.J., Schaeffer A.J. Urinary tract infections in women. Med Clin North Am. 2011;95(1):27–41. - PubMed
    1. Griebling T.L. Urologic diseases in America project: trends in resource use for urinary tract infections in women. J Urol. 2005;173(4):1281–1287. - PubMed
    1. Gupta K., Hooton T.M., Naber K.G. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103–e120. - PubMed
    1. Zalmanovici Trestioreanu A., Green H., Paul M., Yaphe J., Leibovici L. Antimicrobial agents for treating uncomplicated urinary tract infection in women. Cochrane Database Syst Rev. 2010;10 CD007182. - PMC - PubMed
    1. Raz R., Chazan B., Dan M. Cranberry juice and urinary tract infection. Clin Infect Dis. 2004;38(10):1413–1419. - PubMed

Publication types

Associated data