Oseltamivir-resistant pandemic (H1N1) 2009 virus infections, United States, 2010-11
- PMID: 22305467
- PMCID: PMC3310472
- DOI: 10.3201/eid1802.111466
Oseltamivir-resistant pandemic (H1N1) 2009 virus infections, United States, 2010-11
Abstract
During October 2010-July 2011, 1.0% of pandemic (H1N1) 2009 viruses in the United States were oseltamivir resistant, compared with 0.5% during the 2009-10 influenza season. Of resistant viruses from 2010-11 and 2009-10, 26% and 89%, respectively, were from persons exposed to oseltamivir before specimen collection. Findings suggest limited community transmission of oseltamivir-resistant virus.
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References
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- Centers for Disease Control and Prevention. Update: influenza activity—United States, 2009–10 season. MMWR Morb Mortal Wkly Rep. 2010;59:901–8. - PubMed
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- Ives JAL, Carr JA, Mendel DB, Tai CY, Lambkin R, Kelly L, et al. The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo. Antiviral Res. 2002;55:307–17. 10.1016/S0166-3542(02)00053-0 - DOI - PubMed
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