Common signaling networks characterize leukemia-initiating cells in acute myeloid leukemia
- PMID: 22305558
- DOI: 10.1016/j.stem.2012.01.008
Common signaling networks characterize leukemia-initiating cells in acute myeloid leukemia
Abstract
Identification and characterization of leukemia-initiating cells (LICs) is important to understand leukemogenesis and develop novel therapies for leukemia. In this issue of Cell Stem Cell, Gibbs et al. (2012) demonstrate that common active signaling pathways in LICs may be targeted to treat acute myeloid leukemia.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Decoupling of tumor-initiating activity from stable immunophenotype in HoxA9-Meis1-driven AML.Cell Stem Cell. 2012 Feb 3;10(2):210-7. doi: 10.1016/j.stem.2012.01.004. Cell Stem Cell. 2012. PMID: 22305570 Free PMC article.
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