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. 2012 Jun;18(3):363-5.
doi: 10.1016/j.anaerobe.2012.01.004. Epub 2012 Jan 24.

Production and characterization of Clostridium perfringens recombinant β toxoid

Adalgisa Milach  1 , João Rodrigo Gil de los Santos, Carlos Gil Turnes, Angela Nunes Moreira, Ronnie Antunes de Assis, Felipe Masiero Salvarani, Francisco Carlos Faria Lobato, Fabricio Rochedo Conceição
Affiliations

Production and characterization of Clostridium perfringens recombinant β toxoid

Adalgisa Milach et al. Anaerobe. 2012 Jun.

Abstract

In this work, we produced and evaluated a vaccine based on a β toxoid of Clostridium perfringens type C produced in Escherichia coli (rBT). The non-toxic rBT was innocuous for mice and induced 14 IU mL(-1) of β antitoxin in rabbits, complying with the European Pharmacopeia and CFR9 - USDA guidelines.

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