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Meta-Analysis
. 2012 Feb 5;44(3):257-9.
doi: 10.1038/ng.1080.

Common variants at 11p13 are associated with susceptibility to tuberculosis

Thorsten Thye  1 , Ellis Owusu-Dabo, Fredrik O Vannberg, Reinout van Crevel, James Curtis, Edhyana Sahiratmadja, Yanina Balabanova, Christa Ehmen, Birgit Muntau, Gerd Ruge, Jürgen Sievertsen, John Gyapong, Vladyslav Nikolayevskyy, Philip C Hill, Giorgio Sirugo, Francis Drobniewski, Esther van de Vosse, Melanie Newport, Bachti Alisjahbana, Sergey Nejentsev, Tom H M Ottenhoff, Adrian V S Hill, Rolf D Horstmann, Christian G Meyer
Affiliations
Meta-Analysis

Common variants at 11p13 are associated with susceptibility to tuberculosis

Thorsten Thye et al. Nat Genet. .

Abstract

After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

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Figures

Figure 1
Figure 1
Association plot of the chromosome 11 hit region with markers identified by imputation in the Ghanaian data set (red, orange and grey diamonds) and of the meta-analysis (blue diamond). Genes in the long range vicinity are given.
See this image and copyright information in PMC

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