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Case Reports
. 2012 Jan;4(1):5-9.
doi: 10.1159/000335999. Epub 2012 Jan 11.

Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate

Masaya Ishibashi  1 , Taku Fujimura, Akira Hashimoto, Takahiro Haga, Kaoru Onami, Akira Tsukada, Yumi Kambayashi, Takanori Hidaka, Sadanori Furudate, Ryoko Shimada, Setsuya Aiba
Affiliations
Case Reports

Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate

Masaya Ishibashi et al. Case Rep Dermatol. 2012 Jan.

Abstract

We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m(2) body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.

Keywords: Angiosarcoma; Bisphosphonate; Docetaxel; MMP-9.

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Figures

Fig. 1
Fig. 1
A skin-colored nodule with surgery scar, teleangiectasia and purpura on the scalp.
Fig. 2
Fig. 2
Irregular anastomosing vascular channel lined by a single layer of enlarged endothelial cells between collagen bundles with dense infiltration of lymphocytes. (a ×50; b ×200; original magnification).
Fig. 3
Fig. 3
Enlarged endothelial-like cells and tumor stromas were positive for MMP-9. (×200; original magnification).
See this image and copyright information in PMC

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