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Comment
. 2012 Feb 7;109(6):1814-5.
doi: 10.1073/pnas.1120528109. Epub 2012 Jan 31.

Yet another role for natural killer cells: cytotoxicity in immune regulation and viral persistence

Christine A Biron  1
Affiliations
Comment

Yet another role for natural killer cells: cytotoxicity in immune regulation and viral persistence

Christine A Biron. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
NK cell-mediated cytotoxicity in the regulation of immune responses to viral infections. New work is revealing a role for NK cell-mediated killing in immune regulation during LCMV infection. The effects have been reported to be delivered to either CD8 (3) or CD4 (11) T cells. The observed NK cell-mediated immunoregulatory effects are accompanied by reduced resistance and/or persistence of the viral infection. Studies of MCMV infection, with an important contribution of NK cell-mediated killing to antiviral defense, have shown increased viral persistence in the presence of NK cell defense (6). Together, these observations are establishing a paradigm with the NK cell as the “top dog” in regulating host–virus relationships and challenging the understanding of the race between the virus and the host.
See this image and copyright information in PMC

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References

    1. Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP. Natural killer cells in antiviral defense: Function and regulation by innate cytokines. Annu Rev Immunol. 1999;17:189–220. - PubMed
    1. Vidal SM, Khakoo SI, Biron CA. Natural killer cell responses during viral infections: Flexibility and conditioning of innate immunity by experience. Curr Opin Virol. 2011;1:497–512. - PMC - PubMed
    1. Lang PA, et al. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci USA. 2012;109:1210–1215. - PMC - PubMed
    1. Bukowski JF, Woda BA, Habu S, Okumura K, Welsh RM. Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo. J Immunol. 1983;131:1531–1538. - PubMed
    1. Su HC, et al. NK cell functions restrain T cell responses during viral infections. Eur J Immunol. 2001;31:3048–3055. - PubMed

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