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Comparative Study
. 2012 Feb;107(1):142-4.
doi: 10.1590/s0074-02762012000100021.

Comparative evaluation under routine conditions of the nitrate reduction assay, the proportion assay and the MGIT 960 assay for drug susceptibility testing of clinical isolates of Mycobacterium tuberculosis

Leila de Souza Fonseca  1 , Gisele Betzler de Oliveira Vieira, Luciana Fonseca Sobral, Elizabete Oliveira Ribeiro, Anna Grazia Marsico
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Free article
Comparative Study

Comparative evaluation under routine conditions of the nitrate reduction assay, the proportion assay and the MGIT 960 assay for drug susceptibility testing of clinical isolates of Mycobacterium tuberculosis

Leila de Souza Fonseca et al. Mem Inst Oswaldo Cruz. 2012 Feb.
Free article

Abstract

The performance of the nitrate reductase assay (NRA) was compared with the proportion method (PM) on Lowenstein-Jensen medium and the BACTEC MGIT960 assay under routine conditions using 160 clinical isolates of Mycobacterium tuberculosis with a high proportion of resistant strains. The mean time to obtain results was 8.8 days and the overall agreements between NRA and PM and NRA and M960 were 95% and 94%, respectively. NRA was easy to perform and represents a useful tool for the rapid screening of drug-resistant M. tuberculosis strains in low-resource countries.

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