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Review
. 2012 Apr;58(4):680-9.
doi: 10.1373/clinchem.2011.167494. Epub 2012 Feb 6.

Established and emerging markers of kidney function

Michael A Ferguson  1 , Sushrut S Waikar
Affiliations
Review

Established and emerging markers of kidney function

Michael A Ferguson et al. Clin Chem. 2012 Apr.

Abstract

Background: The kidney performs a multitude of essential functions to maintain homeostasis. In clinical medicine, glomerular filtration rate (GFR) provides the best index of overall kidney function, and proteinuria adds additional information on renal and nonrenal prognosis. Several novel biomarkers of kidney injury and function are under investigation.

Content: Plasma creatinine concentration is the most widely used measure for estimation of GFR. Plasma cystatin C and β-trace protein may eventually prove to be superior to creatinine. GFR may be measured directly by use of exogenous filtration markers, although their role is primarily limited to the research setting. Real-time, noninvasive measurement of GFR by using fluorescently labeled markers may be available in the future. Novel biomarkers of tubular injury such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, liver-type fatty acid binding protein, N-acetyl-β-(D)-glucosaminidase, and interleukin-18 may enable the early detection of acute kidney injury before or in the absence of a change in GFR.

Summary: A variety of methods are available to assist clinicians in the assessment of kidney function and injury. Ongoing investigation will help determine the utility of several new markers and clarify their role in the care of patients with and at risk for kidney disease.

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Conflict of interest statement

Authors’ Disclosures or Potential Conflicts of Interest: No authors declared any potential conflicts of interest.

References

    1. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8:R204–12. - PMC - PubMed
    1. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11:R31. - PMC - PubMed
    1. Smith HW. The kidney: structure and function in health and disease. New York: Oxford University Press, Inc; 1951.
    1. Myers GL, Miller WG, Coresh J, Fleming J, Greenberg N, Greene T, et al. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006;52:5–18. - PubMed
    1. [Accessed October 2011];National Kidney Disease Education Program. http://www.nkdep.nih.gov/labprofessionals/estimate_report_gfr.htm.