Review
doi: 10.1152/physiol.00041.2011.
Slc13a1 and Slc26a1 KO models reveal physiological roles of anion transporters
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- PMID: 22311966
- DOI: 10.1152/physiol.00041.2011
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Review
Slc13a1 and Slc26a1 KO models reveal physiological roles of anion transporters
Physiology (Bethesda).
2012 Feb.
Free article
Abstract
Anion transporters NaS1 (SLC13A1) and Sat1 (SLC26A1) mediate sulfate (re)absorption across renal proximal tubule and small intestinal epithelia, thereby regulating blood sulfate levels. Disruption of murine NaS1 and Sat1 genes leads to hyposulfatemia and hypersulfaturia. Sat1-null mice also exhibit hyperoxalemia, hyperoxaluria, and calcium oxalate urolithiasis. This review will highlight the current pathophysiological features of NaS1- and Sat1-null mice resulting from alterations in circulating sulfate and oxalate anion levels.
Comment in
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Re: Slc13a1 and Slc26a1 KO models reveal physiological roles of anion transporters.J Urol. 2012 Sep;188(3):1044. doi: 10.1016/j.juro.2012.05.038. Epub 2012 Jul 23. J Urol. 2012. PMID: 22883809 No abstract available.
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