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Review
. 2012 Feb;27(1):7-14.
doi: 10.1152/physiol.00041.2011.

Slc13a1 and Slc26a1 KO models reveal physiological roles of anion transporters

Daniel Markovich  1
Affiliations
Free article
Review

Slc13a1 and Slc26a1 KO models reveal physiological roles of anion transporters

Daniel Markovich. Physiology (Bethesda). 2012 Feb.
Free article

Abstract

Anion transporters NaS1 (SLC13A1) and Sat1 (SLC26A1) mediate sulfate (re)absorption across renal proximal tubule and small intestinal epithelia, thereby regulating blood sulfate levels. Disruption of murine NaS1 and Sat1 genes leads to hyposulfatemia and hypersulfaturia. Sat1-null mice also exhibit hyperoxalemia, hyperoxaluria, and calcium oxalate urolithiasis. This review will highlight the current pathophysiological features of NaS1- and Sat1-null mice resulting from alterations in circulating sulfate and oxalate anion levels.

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