Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012:4:4.
doi: 10.3410/M4-4. Epub 2012 Feb 1.

Reduced vancomycin susceptibility among clinical Staphylococcus aureus isolates ('the MIC Creep'): implications for therapy

Abhay Dhand, George Sakoulas

Reduced vancomycin susceptibility among clinical Staphylococcus aureus isolates ('the MIC Creep'): implications for therapy

Abhay Dhand et al. F1000 Med Rep. 2012.

Abstract

Methicillin-resistant S. aureus (MRSA) has emerged as the most common hospital-acquired pathogen and is associated with increased morbidity and mortality compared with other strains. Vancomycin has been the cornerstone of treatment of patients with serious MRSA infections for some decades and while more than 99% of clinical S. aureus isolates remain susceptible to vancomycin, we are beginning to see strains of MRSA with reduced susceptibility. This review discusses this phenomenon, the predictors of infection with such forms of MRSA, and current and future management options.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Population analysis amoung hVISA and VISA of heterogeneous resistance to vancomycin
Figure 2.
Figure 2.. Heteroresistance to vancomycin therapy amoung S. aureus isolates
See this image and copyright information in PMC

References

    1. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39:309–17. doi: 10.1086/421946. - DOI - PubMed

    2. F1000 Factor 6

      Evaluated by George Sakoulas 18 Jan 2012

    1. Soriano A, Martinez JA, Mensa J, Marco F, Almela M, Moreno-Martinez A, Sanchez F, Munoz I, Jimenez de Anta MT, Soriano E. Pathogenic significance of methicillin resistance for patients with Staphylococcus aureus bacteremia. Clin Infect Dis. 2000;30:368–73. doi: 10.1086/313650. - DOI - PubMed

    2. F1000 Factor 6

      Evaluated by George Sakoulas 18 Jan 2012

    1. Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, Carmeli Y. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis. 2003;36:53–9. doi: 10.1086/345476. - DOI - PubMed
    1. Tenover FC, Moellering RC., Jr The rationale for revising the Clinical and Laboratory Standards Institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus. Clin Infect Dis. 2007;44:1208–15. doi: 10.1086/513203. - DOI - PubMed

    2. F1000 Factor 6

      Evaluated by George Sakoulas 18 Jan 2012

    1. Sakoulas G, Moellering RC., Jr Increasing antibiotic resistance among methicillin-resistant Staphylococcus aureus strains. Clin Infect Dis. 2008;46:S360–7. doi: 10.1086/533592. - DOI - PubMed