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. 2011 Dec;6(12):1839-41.

Anti-adipogenic activity of Cordyceps militaris in 3T3-L1 cells

Qing Liu  1 , In Pyo Hong, Mi-Jeong Ahn, Hwan-Soo Yoo, Sang-Bae Han, Bang Yeon Hwang, Mi Kyeong Lee
Affiliations
  • PMID: 22312720

Anti-adipogenic activity of Cordyceps militaris in 3T3-L1 cells

Qing Liu et al. Nat Prod Commun. 2011 Dec.

Abstract

Inhibition of adipocytes differentiation is suggested to be an important strategy for prevention and/or treatment of obesity. In our present study, Cordyceps militaris showed significant inhibitory activity on adipocyte differentiation in 3T3-L1 preadipocytes as assessed by measuring fat accumulation using Oil Red O staining. Activity-guided fractionation led to the isolation of cordycepin (1), guanosine (2) and tryptophan (3) as active compounds. All the three compounds were more effective in the prevention of early stage of adipogenesis than in lipolysis. In addition, combinational treatment of three compounds significantly increased anti-adipogenic activity.

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