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Multicenter Study
. 2012 Apr 24;26(7):887-90.
doi: 10.1097/QAD.0b013e328351e721.

Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection

Elizabeth Hamlyn  1 , Stephen Hickling, Kholoud Porter, John Frater, Rodney Phillips, Mark Robinson, Nicola E Mackie, Steve Kaye, Myra McClure, Sarah Fidler; SPARTAC Investigators
Collaborators, Affiliations
Multicenter Study

Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection

Elizabeth Hamlyn et al. AIDS. .

Abstract

CXCR4-tropic (X4) HIV-1 variants are associated with faster disease progression compared with CCR5-tropic variants; however, the mechanism for this is unclear. We measured T-cell activation in 120 individuals with primary HIV-1 infection. X4-utilizing variants, determined genotypically, were present in 8.3% of the participants and were associated with higher levels of CD4 T-cell activation, even after adjusting for other prognostic factors. Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus.

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