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. 2012 Jun;19(3):524-33.
doi: 10.1007/s12350-012-9522-0.

Effects of patient movement on measurements of myocardial blood flow and viability in resting ¹⁵O-water PET studies

Kazuhiro Koshino  1 , Hiroshi Watabe, Junichiro Enmi, Yoshiyuki Hirano, Tsutomu Zeniya, Shinji Hasegawa, Takuya Hayashi, Shigeru Miyagawa, Yoshiki Sawa, Jun Hatazawa, Hidehiro Iida
Affiliations

Effects of patient movement on measurements of myocardial blood flow and viability in resting ¹⁵O-water PET studies

Kazuhiro Koshino et al. J Nucl Cardiol. 2012 Jun.

Abstract

Background: Patient movement has been considered an important source of errors in cardiac PET. This study was aimed at evaluating the effects of such movement on myocardial blood flow (MBF) and perfusable tissue fraction (PTF) measurements in intravenous ¹⁵O-water PET.

Methods: Nineteen ¹⁵O-water scans were performed on ten healthy volunteers and three patients with severe cardiac dysfunction under resting conditions. Motions of subjects during scans were estimated by monitoring locations of markers on their chests using an optical motion-tracking device. Each sinogram of the dynamic emission frames was corrected for subject motion. Variation of regional MBF and PTF with and without the motion corrections was evaluated.

Results: In nine scans, motions during ¹⁵O-water scan (inter-frame (IF) motion) and misalignments relative to the transmission scan (inter-scan (IS) motion) larger than the spatial resolution of the PET scanner (4.0 mm) were both detected by the optical motion-tracking device. After correction for IF motions, MBF values changed from 0.845 ± 0.366 to 0.780 ± 0.360 mL/minute/g (P < .05). In four scans with only IS motion detected, PTF values changed significantly from 0.465 ± 0.118 to 0.504 ± 0.087 g/mL (P< .05), but no significant change was found in MBF values.

Conclusions: This study demonstrates that IF motion during ¹⁵O-water scan at rest can be source of error in MBF measurement. Furthermore, estimated MBF is less sensitive than PTF values to misalignment between transmission and ¹⁵O-water emission scans.

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Figures

Figure 1
Figure 1
Schematic diagram of the correction for IS and IF motions
Figure 2
Figure 2
Differences between PTF values with and without the motion corrections. IS, Inter-scan motion; IF, inter-frame motion; NE, no significant motion. IS + IF − IS and IS + IF − IF are groups corrected for IS and IF motion in the IS + IF group, respectively
Figure 3
Figure 3
Changes in PTF values in the absolute scale by the MCs. IS, Inter-scan motion; IF, inter-frame motion; NE, no significant motion. IS + IF − IS and IS + IF − IF are groups corrected for IS and IF motion in the IS + IF group, respectively. A data point indicates an averaged value for each scan
Figure 4
Figure 4
Effect of an IS motion of 5.0 mm on MBF and PTF of a normal subject in IS motion group
Figure 5
Figure 5
Relative variability of regional MBF due to effects of global motion. IS, Inter-scan motion; IF, inter-frame motion; NE represents no significant motion. IS + IF − IS and IS + IF − IF are groups corrected for IS and IF motion in the IS + IF group, respectively
Figure 6
Figure 6
Relative variability of regional PTF due to effects of global motion. IS, Inter-scan motion; IF, inter-frame motion; NE represents no significant motion. IS + IF − IS and IS + IF − IF are groups corrected for IS and IF motion in the IS + IF group, respectively
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