Function biomedical informatics research network recommendations for prospective multicenter functional MRI studies

Abstract

This report provides practical recommendations for the design and execution of multicenter functional MRI (MC-fMRI) studies based on the collective experience of the Function Biomedical Informatics Research Network (FBIRN). The study was inspired by many requests from the fMRI community to FBIRN group members for advice on how to conduct MC-fMRI studies. The introduction briefly discusses the advantages and complexities of MC-fMRI studies. Prerequisites for MC-fMRI studies are addressed before delving into the practical aspects of carefully and efficiently setting up a MC-fMRI study. Practical multisite aspects include: (i) establishing and verifying scan parameters including scanner types and magnetic fields, (ii) establishing and monitoring of a scanner quality program, (iii) developing task paradigms and scan session documentation, (iv) establishing clinical and scanner training to ensure consistency over time, (v) developing means for uploading, storing, and monitoring of imaging and other data, (vi) the use of a traveling fMRI expert, and (vii) collectively analyzing imaging data and disseminating results. We conclude that when MC-fMRI studies are organized well with careful attention to unification of hardware, software and procedural aspects, the process can be a highly effective means for accessing a desired participant demographics while accelerating scientific discovery.

Figure 1

Example showing the FBIRN wiki page. This demonstrates an effective means for rapid sharing of critical protocol information between sites, as implemented in the most recent FBIRN study.

Figure 2

Screen capture of FBIRN Data Tracking Dashboard, which shows status of data collection for each site.

Figure 3

Influence of RF excitation method on image quality, using (A,C) spectral-spatial (spsp) or (B,D) fatsat options. The measured slice profile with spsp demonstrates increased width and substantial sidelobes (A) that cause partial saturation of adjacent slices, and result in contrast changes in EPI images (B). Fatsat methods can provide better slice profiles (C) and diminished saturation effects (D). Since spsp is the default on GE scanners while fatsat is the default on Siemens, care must be used to standardize. (Single-slice profile measurements by T. Liu and K. Lu, UCSD; images acquired by B. Mueller, U. Minn. TR = 2000 ms, FA = 77°, 4 mm slice/1 mm gap prescribed).