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Review
. 2012 May;90(5):913-24.
doi: 10.1002/jnr.22829. Epub 2012 Feb 8.

Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: a review

Casey M O'Dell  1 , Arabinda Das, Gerald Wallace 4th, Swapan K Ray, Naren L Banik
Affiliations
Review

Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: a review

Casey M O'Dell et al. J Neurosci Res. 2012 May.

Abstract

Despite years of research, epilepsy remains a poorly understood disorder. In the past several years, work has been conducted on a variety of projects with the goal of better understanding the pathogenesis and progression of mesial temporal lobe epilepsy (MTLE), in particular, and how to exploit those properties to generate innovative therapies for treatment of refractory epilepsies. This review seeks to give an overview of common morphological and biochemical changes associated with epilepsy and proposed treatments to address those changes. Furthering the understanding of ictogenesis and epileptogenesis remains an important goal for scientists seeking to find more effective treatments for MTLE.

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Figures

Fig. 1.
Fig. 1.
Schematic representation of factors leading to epileptogenesis.
See this image and copyright information in PMC

References

    1. Araujo IM, Carreira BP, Carvalho CM, Carvalho AP. 2010. Calpains and delayed calcium deregulation in excitotoxicity. Neurochem Res 35:1966–1969. - PubMed
    1. Arganaraz GA, Konno AC, Perosa SR, Santiago JF, Boim MA, Vidotti DB, Varella PP, Costa LG, Canzian M, Porcionatto MA, Yacubian EM, Sakamoto AC, Carrete H Jr, Centeno RS, Amado D, Cavalheiro EA, Junior JA, Mazzacoratti Mda G. 2008. The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis. Epilepsia 49:1348–1357. - PubMed
    1. Aronica E, Zurolo E, Iyer A, de Groot M, Anink J, Carbonell C, van Vliet EA, Baayen JC, Boison D, Gorter JA. 2011. Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. Epilepsia (in press). - PMC - PubMed
    1. Bae EK, Jung KH, Chu K, Lee ST, Kim JH, Park KI, Kim M, Chung CK, Lee SK, Roh JK. 2010. Neuropathologic and clinical features of human medial temporal lobe epilepsy. J Clin Neurol 6:73–80. - PMC - PubMed
    1. Baram TZ, Jensen FE, Brooks-Kayal A. 2011. Does acquired epileptogenesis in the immature brain require neuronal death. Epilepsy Curr 11:21–26. - PMC - PubMed

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