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Review
. 2012 Jan;2(1):a006346.
doi: 10.1101/cshperspect.a006346.

Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

Tony Wyss-Coray  1 , Joseph Rogers
Affiliations
Review

Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

Tony Wyss-Coray et al. Cold Spring Harb Perspect Med. 2012 Jan.

Abstract

Biochemical and neuropathological studies of brains from individuals with Alzheimer disease (AD) provide clear evidence for an activation of inflammatory pathways, and long-term use of anti-inflammatory drugs is linked with reduced risk to develop the disease. As cause and effect relationships between inflammation and AD are being worked out, there is a realization that some components of this complex molecular and cellular machinery are most likely promoting pathological processes leading to AD, whereas other components serve to do the opposite. The challenge will be to find ways of fine tuning inflammation to delay, prevent, or treat AD.

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Figures

Figure 1.
Figure 1.
Brief schematic of the complement system (see text for details).
See this image and copyright information in PMC

References

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