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Case Reports
. 2012 May;50(5):1800-4.
doi: 10.1128/JCM.00150-12. Epub 2012 Feb 8.

Purpureocillium lilacinum as a cause of cavitary pulmonary disease: a new clinical presentation and observations on atypical morphologic characteristics of the isolate

Ziauddin Khan  1 , Suhail Ahmad, Fahad Al-Ghimlas, Sana Al-Mutairi, Leena Joseph, Rachel Chandy, Deanna A Sutton, Josep Guarro
Affiliations
Case Reports

Purpureocillium lilacinum as a cause of cavitary pulmonary disease: a new clinical presentation and observations on atypical morphologic characteristics of the isolate

Ziauddin Khan et al. J Clin Microbiol. 2012 May.

Abstract

The first case of cavitary pulmonary disease caused by Purpureocillium lilacinum is described. The isolate showed atypical microscopic characteristics similar to Acremonium and Fusarium spp., which necessitated molecular identification by sequencing of multiple conserved loci. The patient responded to voriconazole, reinforcing its therapeutic efficacy for P. lilacinum infections.

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Figures

Fig 1
Fig 1
(A) Initial chest computed tomography (CT) imaging showing cavitating lesion in anterior segment of lung left upper lobe (arrow). (B) Follow-up chest CT image showing regression of cavitating lesion after 1 week of voroconazole therapy.
Fig 2
Fig 2
Potassium hydroxide (10%)-calcofluor (0.1%) mount of bronchoalveolar lavage showing septate hyphal elements. Bar, 5 μm.
Fig 3
Fig 3
(A to C) One-week-old slide culture of P. lilacinum (MF3411/10) grown on Sabouraud dextrose agar at 30°C showing Acremonium-like phialides and fusiform conidia.
See this image and copyright information in PMC

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