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. 2012 Jul 1;17(4):e716-20.
doi: 10.4317/medoral.17788.

Epiphany root canal sealer prepared with resinous solvent is irritating to rat subcutaneous tissues

Élcio Daleffe  1 , José-Estevam Vieira-Ozório, José-Estevam Sousa-Neto, Danyel-Elias da-Cruz-Perez
Affiliations

Epiphany root canal sealer prepared with resinous solvent is irritating to rat subcutaneous tissues

Élcio Daleffe et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Objective: This study assessed the biocompatibility of the Epiphany endodontic sealer prepared with resinous solvent of Epiphany system (Thinning resin) in rat subcutaneous tissues.

Study design: Polyethylene tubes were filled with the sealer and 4 groups were established: GI, Epiphany prepared with 1 drop of resinous solvent (RS); GII, Epiphany prepared with 1 drop of RS and photoactivated; GIII, Epiphany associated with self-etch primer and prepared with 1 drop of RS; GIV, Epiphany associated with self-etch primer, prepared with 1 drop of RS and photoactivated. The filled tubes were implanted into 4 different regions of the dorsum of 20 adult male rats.

Results: After 7, 14 and 21 days, all groups presented a moderate to severe chronic inflammation, necrosis and foreign-body giant cells. At 42 days, although the intensity of chronic inflammatory reaction decreased, the other features still were observed.

Conclusion: The Epiphany sealer prepared with the RS was irritating to rat subcutaneous tissues.

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Figures

Figure 1
Figure 1
Group III (Epiphany associated with self-etch primer and prepared with 1 drop of resinous solvent), 7 days – Severe chronic inflammatory reaction, residual sealer (white arrow) and foreign body giant cells (yellow arrow) (hematoxylin-eosin, original magnification, x100).
Figure 2
Figure 2
Group IV (Epiphany associated with self-etch primer, prepared with 1 drop of resinous solvent and photoactivated), 14 days – Large quantity of residual sealer beyond the connective tissue adjacent to open extremity of the tube, foci of necrosis (arrows) and severe inflammation (hematoxylin-eosin, original magnification, x100).
Figure 3
Figure 3
Group I (Epiphany prepared with 1 drop of resinous solvent), 21 days – Large quantity of residual sealer (yellow arrow), with foreign body giant cells (black arrow) (hematoxylin-eosin, original magnification, x100).
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