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. 2012 Sep 1;17(5):e739-44.
doi: 10.4317/medoral.17950.

Immunohistochemical expression of EGFR in oral leukoplakia: association with clinicopathological features and cellular proliferation

Daniela-Cotta Ribeiro  1 , Frederico-Omar Gleber-Netto, Sílvia-Ferreira Sousa, Vanessa-de-Fátima Bernardes, Mauro-Henrique-Nogueira Guimarães-Abreu, Maria-Cássia-Ferreira Aguiar
Affiliations

Immunohistochemical expression of EGFR in oral leukoplakia: association with clinicopathological features and cellular proliferation

Daniela-Cotta Ribeiro et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Objectives: To investigate the immunoexpression of epidermal growth factor receptor (EGFR) in a sample of oral leukoplakias (OL) and to determine the receptor' s association with dysplasia, tobacco consumption, lesion site, and proliferation rate. Although EGFR should be overexpressed in some oral leukoplakias, the factors that may interfere with this expression and the influence of this receptor on epithelial proliferation have yet to be investigated.

Study design: Samples of oral leukoplakias (48) and of normal oral epithelium (10) were immunohistologically examined for expression of EGFR. Immunohistochemistry for Ki-67, and p27 were also performed in leukoplakias. EGFR expression was associated with clinical and pathological features.

Results: EGFR was positive in 62.5% of the leukoplakias and 50% of normal oral epithelium. The number of EGFR positive OL located in high-risk sites was significantly higher than EGFR positive OL located in low-risk sites. Most of the p27 negative leukoplakias were EGFR positive, and the p27 index in the parabasal layer was diminished in the presence of dysplasia. Positivity for EGFR was not associated with dysplasia, tobacco exposure, or Ki-67.

Conclusion: EGFR is expressed in leukoplakia regardless of dysplasia, but EGFR positivity should be more frequent in lesions sited in areas of high cancer risk. The association between EGFR and p27 may represent an important mechanism in the control of cellular proliferation and malignant progression of oral epithelium and therefore warrants further investigation.

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Figures

Figure 1
Figure 1
(A) Membranous staining for EGFR in oral leukoplakia (arrowheads). Immunohistochemical staining, original magnification 400x.
See this image and copyright information in PMC

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References

    1. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36:575–80. - PubMed
    1. van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 2009;45:317–23. - PubMed
    1. Warnakulasuriya S, Reibel J, Bouquot J, Dabelsteen E. Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J Oral Pathol Med. 2008;37:127–33. - PubMed
    1. Dietrich T, Reichart PA, Scheifele C. Clinical risk factors of oral leukoplakia in a representative sample of the US population. Oral Oncol. 2004;40:158–63. - PubMed
    1. Gümüş ZH, Du B, Kacker A, Boyle JO, Bocker JM, Mukherjee P. Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia. Cancer Prev Res (Phila) 2008;1:100–11. - PMC - PubMed