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Comment
. 2012 Feb 9;119(6):1326-7.
doi: 10.1182/blood-2011-12-394429.

Getting rid of refractory hemophilia

Pier Mannuccio Mannucci  1
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Free article
Comment

Getting rid of refractory hemophilia

Pier Mannuccio Mannucci. Blood. .
Free article

Abstract

In a prospective randomized, multicenter study of immune tolerance induction(ITI) in patients with hemophilia A refractory to replacement therapy after the development of alloantibodies that inhibit factor VIII (FVIII) activity, Hay and DiMichele compared two regimens, a low dose of FVIII (50 IU/Kg thrice weekly)or a high-dose (200 IU/kg daily

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