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Comment
. 2012 Feb 8;4(120):120ps2.
doi: 10.1126/scitranslmed.3003728.

Escaping ALK inhibition: mechanisms of and strategies to overcome resistance

Christine M Lovly  1 , William Pao
Affiliations
Comment

Escaping ALK inhibition: mechanisms of and strategies to overcome resistance

Christine M Lovly et al. Sci Transl Med. .

Abstract

Mutated anaplastic lymphoma kinase (ALK) drives the development of multiple tumor types, and ALK tyrosine kinase inhibitors such as crizotinib have been validated as targeted therapeutics. Unfortunately, as with other oncogene-driven tumors, therapeutic resistance invariably develops. In Science Translational Medicine, two recent studies provide new insight into mechanisms of resistance to ALK tyrosine kinase inhibitors and possible strategies to overcome this resistance.

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  • Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers.
    Katayama R, Shaw AT, Khan TM, Mino-Kenudson M, Solomon BJ, Halmos B, Jessop NA, Wain JC, Yeo AT, Benes C, Drew L, Saeh JC, Crosby K, Sequist LV, Iafrate AJ, Engelman JA. Katayama R, et al. Sci Transl Med. 2012 Feb 8;4(120):120ra17. doi: 10.1126/scitranslmed.3003316. Epub 2012 Jan 25. Sci Transl Med. 2012. PMID: 22277784 Free PMC article.

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