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. 2012 May;137(1-3):45-9.
doi: 10.1016/j.schres.2012.01.019. Epub 2012 Feb 9.

Early cannabis use and schizotypal personality disorder symptoms from adolescence to middle adulthood

Deidre M Anglin  1 , Cheryl M Corcoran, Alan S Brown, Henian Chen, Quenesha Lighty, Judith S Brook, Patricia R Cohen
Affiliations

Early cannabis use and schizotypal personality disorder symptoms from adolescence to middle adulthood

Deidre M Anglin et al. Schizophr Res. 2012 May.

Abstract

Background: While increasing evidence suggests that cannabis use may play a role in the development of schizophrenia in some young people, less is known about the strength and specificity of its relationship to latent schizophrenia liability, i.e., schizotypal personality disorder traits.

Aims: Determine the predictive value of cannabis use during childhood and early adolescence on schizotypal personality disorder (SPD) symptoms projecting into adulthood, using a community-based longitudinal cohort from upstate New York.

Method: Prospective data from 804 participants was used to determine associations between early cannabis use and later schizotypal symptoms, accounting for important potential confounds (e.g., adolescent schizotypal symptoms).

Results: Cannabis use with onset prior to age 14 strongly predicted SPD symptoms in adulthood, independent of early adolescent SPD symptoms, major depression, anxiety disorder, other drug use, and cigarette use. There was no interaction effect of early cannabis use and early adolescent SPD symptoms on SPD symptoms into adulthood.

Conclusions: Our data provide further support for a strong association of early cannabis use with the development of symptoms characteristic of schizophrenia spectrum disorders. As with studies in schizophrenia, early SPD symptoms could not fully explain the association of early cannabis use with later schizotypal symptoms. The mechanisms that underlie the association of cannabis use and schizotypal symptoms in a developmental context deserve further exploration.

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Conflict of interest statement

Conflict of Interest

All authors declare no actual or potential conflict of interest.

Figures

Figure 1
Figure 1
Standardized schizotypal personality disorder symptoms from age 13 to 35 for participants with (Dashed Line) and without (Solid Line) early cannabis use
See this image and copyright information in PMC

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