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Comment
. 2012 Feb 9;73(3):405-7.
doi: 10.1016/j.neuron.2012.01.009.

Life-or-death decisions upon axonal damage

Francesco Roselli  1 , Pico Caroni
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Free article
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Life-or-death decisions upon axonal damage

Francesco Roselli et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Hu et al. (2012) report that upon axonal damage, CHOP and XBP1 unfolded protein response pathways are not recruited equally and have opposite effects on neuronal survival. XBP1 pathway boosting may represent a valuable neuroprotective strategy.

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